I think Capcom should make the next game like The Evil Within with RE4 gameplay, but have a lot of creepy locations, zombies, and bosses, and tone down the amount of weapons just a tad bit. I think an open world game could be very unique. They're always confining you to corridors to make it scary, when they could expand the world.
I don't like RE without zombies and viruses. When it's the mould and vampires, it doesn't feel like RE anymore. The idea of this mould is just so Capcom can make their imagination run like crazy.
I also don't like the idea of a shopping system, because that's barely realistic. I think there should be a personal workshop instead, for crafting. But you need to collect a lot of materials first. Like, a lot. I would say that's more akin to a horror experience.