I don't think there's anything wrong with Alyssa's design per se (if anything she should look older with a teenage daughter) but the faces are a bit weird. I think they've gone down the road of mocap for everything since the RE engine came along, and the results have often been mixed. More annoying is the acting and writing style where people say "what the fuck, oh shit" all the time, I prefer the older b-movie charm.
The overall character design of Alyssa is fine... if you're not looking at her face. It's hard to get around that.
I just watched the new trailer again and it still looks REALLY bad. The lacking expressions could be making it worse than the face on the model.
I've actually been mostly positive with how classic characters have been updated for the RE Engine in the past - and it's their faces and how they're animated that makes or breaks a character's design for me.
Leon (in RE2 Remake, especially) is perfect.
Marvin is perfect.
Ada is perfect.
Jill is perfect.
Carlos is perfect.
Nicolai and gang? Perfect.
Claire is definitely a new take, but I like her - maintaining a soft, nurturing look that's suitable. No overpowering jawline.
Chris is back to his uncanny valley meat-head ape self again after Capcom caved to the RE5/RE6 plebs bitching, but whatever.
Focusing on Jill for comparison, I think her new face model (hot Russian chick) is actually my favorite iteration of her yet - even above Julia Voth. I see RE3 Remake Jill as THE definitive Jill Valentine now - both in looks and in character. Capcom struck a perfect balance between tough and feminine with this new Jill, hence why they probably used a Russian model for reference. I've found some Slavic women have naturally strong jawlines and are quite independent, but they're still clearly women with the rest of their features.
New Alyssa on the other hand? That jawline is over-tuned - and I think she looks too generic. Maybe they should've kept her old hairstyle, at least.
On the flipside to that, it wasn't until RE3 Remake that I realized Voth never fit as Jill for me. Voth's face was possibly TOO traditionally soft, feminine and pretty for Jill. Couple that with the mundane/stoneface writing/acting we got in RE1 Remake (being that masterpiece's only area that could use improvement), I couldn't take Voth's Jill seriously as somebody who was supposed to be a dangerous special forces officer.
For that reason, I'd also take the primal "fucks" and "shits" over B-movie cheese any day.
Just like some of the classic RE game design, I think the cheesy acting was just a product of its time due to hardware limitations, translations, etc. I don't believe the cheese was ever intentional - and it's my preference that it stays gone forever. The memes are fun, but these people are supposed to be cops and special forces - not cornballs. Aside from the occasional quirky merchant, overconfident quip or eccentric megalomaniac, I personally don't want any B-movie charm in my Resident Evil games - but I do want characters that sound convincing and look the part!