1) In Japan, Darkside Chronicles is the 5th Biohazard game to be released for Wii.
2) In North America, Darkside Chronicles was the 4th Resident Evil game to be released for Wii.
3) In Japan, Darkside Chronicles was released after every other Biohazard game on the Wii. In North America, Darkside Chronicles came out shortly before Resident Evil Archives: Resident Evil Zero.
4) In Japan, two variation packages were released. One with the game by itself, and another as a Collector's Package that contained a DVD, mini-soundtrack, special box and unique disc art.
5) Darkside Chronicles is the fourth time a Biohazard game was released in different calendar years in North America and Japan. Darkside Chronicles was released in 2009 in North America, and 2010 in Japan.
6) Darkside Chronicles is the fifth game in series history to be played primarily in first person, and the second entirely on-rails game.
7) Darkside Chronicles is the fourth game to feature Claire Redfield as a prominent playable character, after her appearances in Biohazard 2, CODE: Veronica and Gun Survivor 2. It's also the fourth game to feature Leon as a prominent playable character, after Biohazard 2, Biohazard 4 and Biohazard Gaiden. It would be their fifth appearances if Biohazard Degeneration is counted.
8) Darkside Chronicles is the fourth game to feature Ada Wong and the third to feature Hunk, but the first time they are entirely unplayable in spite of their appearance.
9) Darkside Chronicles is the fifth game to feature Chris Redfield, and the sixth to have him playable. However, his role is very minor.
10) Darkside Chronicles is the third game to feature Steve Burnside, after CODE: Veronica and Gun Survivor 2.
11) Darkside Chronicles is the second game to feature Krauser, second time to have him playable, and first to have him as a protagonist.
12) Darkside Chronicles is the first time Leon and Chris were both playable in the main game, and second if Extreme Battle Mode in select versions of Biohazard 2 is counted.
13) Darkside Chronicles is the second time the basic plot of CODE: Veronica has been retold through first person gameplay, after Gun Survivor 2.
14) Darkside Chronicles is the second game in the series to take place in the year 2002. The first was Gun Survivor 4.
15) Alyson Court reprises her role as Claire Redfield for the fourth time, after Biohazard 2, CODE: Veronica and Degeneration. Claire is the only character in the series to never change voice actors.
16) Sally Cahill returns to voice Ada after being absent in Umbrella Chronicles.
17) Paul Mercier reprises his role as Leon, after Biohazard 4 and Degeneration.
18) Jim Ward reprises his role as Krauser, after Biohazard 4.
19) Roger Craig Smith reprises his role as Chris Redfield, after Biohazard 5.
20) DC Douglass reprises his role as Albert Wesker, after Umbrella Chronicles and Biohazard 5.
21) Ada and Chris are the only characters to have different voice actors between Umbrella Chronicles and Darkside Chronicles.
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