I personally think anything is possible- but we've seen enough of Wesker. He's fulfilled his purpose and exclaimed his intentions, failing to carry them out. I just don't think someone that "baddass" like Wesker should be made to skulk out of the abyss with his tail between his legs trying to execute "plan B."
It also really bothers me that we saw Ada in 2005 and have yet to know anything else about her. I really hope she shows up in Damnation. And I wouldn't mind seeing Rebecca either- considering she had a whole game to herself and Barry at least made a cameo in RE:3. I like to see more of the characters "personal lives" instead of having to play a game that has virtually no emotion to it--- kinda failed to go all out after 2005, excluding Jill and Chris.

The only way I see him return is that uroboros gave him the ability to regenerate his whole body from a simple cell. It's possible.

Actually that would be impossible, ridiculous and totally forced. Let him die already people.

How is it impossible? that movie (4-D something) had a doctor who could do something similar to that.

He'll come back as something totally original, like a giant leech.

I really wish that he survived, but come on, how could he have. A lava bath and 2 RPG's? If that doesn't kill him what would? Plus if he did by some miracle survive that, he did inject himself with the uroboros virus so he's some messed up monster now I'm pretty disappointed they killed him though.

I think that they are going to have a wesker clone or something in a future game. Wesker was behind practically everything in the RE games and it wont be the same without him.

HE IS DEAD. He is good as a double dead meat being sold at markets in phil XD
No one could ever survive RPGs in the RE WORLD, remember, RPG blows up any infected!! XD

Yeah, he is dead. Which means that he can never ever come back outside of in-between story stuff (i.e. in flashbacks). But I think a lot of fans don't want to believe it when they saw their number one villain get his just desserts. Can't blame ya (fans who moan), but face it... Nobody lives after being melted to nothing in a volcano, lol! Unless you were like made of fire or were a God, maybe you could survive. But not Wesker.

Even the game's staff confessed he died. So you should take their word for it. I would not rule out the chance to clone him at some stage, but that just seems awfully random and may be even desperate. But never say never.

We already have a horror character who does this. His name is John Kramer in Saw!

Don't worry people, while they may not have him in the next game story mode, im sure we would be able to get him on a multiplayer game mode. He's dead and gone people. time to move on, he was a great villain, he would die eventually.

He's dead because logically, a single cell would not exist in a pool of lava.

I know logic doesn't work in video games, but still.