I still play RE5's main campaign occasionally, but I'm the first to admit that it can get a bit stale after a while. I know that a lot of people, including myself, come up with different settings or weapons to exclusively use on certain playthroughs to make it challenging or just to keep it fresh. Some that I've come up with:

Western:

Sepia filter, Warrior Chris, Fairytale Sheva, can only use S&W M29, Ithaca M37, Hydra, S75 rifle, all with no upgrades, no unlimited ammo

Cowboys & Indians:

Same as above but Fairytale Sheva and she can only use the longbow

"Realistic:"

BSAA or Stars Chris and BSAA Sheva, begin game with no inventory, can only use things found along the way, no infinite ammo, no use of the inventory space between chapters, if you want to get rid of something, you have to discard it (this one gets pretty challenging, even on veteran)

Classic RE:

Stars Chris and BSAA Sheva, noise filter, no infinite ammo, can only use weapons that were available or had equivalents in REmake (M92, M37, M3, flamethrower, rocket launcher, M500, grenade launcher with explosive/flame/acid), no infinite ammo, no upgrades


Anyone else have some good ideas? I figure it'll be a while until we get our next main RE game, and I'm not buying a 3DS just for Revelations. Anything to extend the value and playtime with RE5 is a good thing.

Those are pretty creative. I am still working my way to the platinum, the game hasn't quite got "stale" for me yet. I can't take too much of the game at one time. 1-2 hours and I have had enough. I still can't even play through Desperate Escape because Josh is very irritating.

Your "Classic RE" scenario bothers me though, not really your fault but it is not "Classic" with Sheva.

I think a One Gun playthrough would be interesting. Not really sure if it is possible, sure Infinite Rocket Launcher could be done but that would be a bit easy I think.

Yeah it's the best that can be done in the confines of the game. If only they released a "Harry Potter Invisibility Cloak" costume for her and allowed you to mute her comments. Then you could just give her no weapons...

That would be great. I would pay money for that. Capcom?

The realistic one sounds like a good way to play. Nice choices.

You have way too much money to spare then. That sounds terrible.

Sheva being there doesn't make it any less 'classic', because RE5 is her game along with Chris. If you are playing a 'classic' mode, then it's playing RE5 with classic settings. Not playing Remake.

My favorite runs are stunrod and handgun only runs and grenade launcher only runs.

Nnice, i like the mode westenr :)

I remeber doing a realistic run on re4 and damn was it hard. ill do one in re5 when i have the chance.

I will try them out since i will hav alot of time at home :)

But wot bout this 'Real RE5?": normal filter, BSAA Chris and BSAA Sheva,
u can ONLY use M92F and no upgrades, no ammo at the start. Can use genardes, heal items.
if playing veteran or professional difficulty, u can sell other weapons or their ammo to earn extra cash to upgrade the M9. If u playing with normal or lower difficulty u can't upgrade ur weapon.
No money at the start, so basically a new RE5 file/savedata, the players can only use M9 and genardes to complete the game.

Sounds cool? or impossible? :P

Near impossible for wesker fights, otherwise it's fine.