Face it folks, he's gone. Even if the rockets missed him {which they didn't}. he was basically up to his neck in molten lava which would have consumed him eventually.

If they did bring him back, it would be a tad hard to come up with a reasonable explanation why. Clone is a definte no no, the only cloning in the re franchise was Sergei. The Wesker children were never clones.

Hid future lies in prequel and flashback world.

What he said. Even if he did come back, he's some crazy uroboros monster thing now thats also been blown to shit and melted in lava. He wouldn't be the same Wesker we know and love.

Wesker's ass was grass, and Chris and Sheva were the lawnmowers. He had it comming.

A mighty fine arse that didn't need be trimmed, might I add!

Gah, ok, I'll stop with the innuendos now.

They'll clone him. I.E. Alien: Resurrection Ripley.

Well the cloning revoluation would be a bit dull considering RE5 already had the whole "Are you telling me I was manufactered?" line from him. So it'd be redundant.

Yeaaa hes dead, sadly

There are actually a lot of folk who are glad that Wesker died. Because they think he was overrated and that the series should not revolve around him. Whether you liked him or not, it hardly matters. He had earned that right. His history with a lot of the characters meant he should have lived on and been killed by other means. But Capcom must have thought it was time for him to go, so there it is.

I will be shocked if they bring him back again. i could understand him living through getting stabbed by a tyrant. but in RE5 he got buried in lava. LAVA!! then 2 rpgs to the head. im sorry, im also a wesker fan, but he is dead. i have no idea what the next mortal enemy for the next RE character story will be since weskers dead though. i dont think capcom pays attention to what games they make.

I think he is alive.

Some part of the T virus allowed him to survive and WHEN the volcano blows up he will gel back together stronger than before. bit like the T-1000 in Terminator Judgement Day.