No doubt about it. End of discussion on that note. It's unbelievable what you can do to a B.O.W. with the knife. Too bad it's only in that game. I'm curious as to how it got so powerful. Did one of the programmers input a 1 instead of a 0 ?

I'm going to have to go with the Handcannon. I say it is the most powerful weapon in the game. In the hands of Leon, he will kill all.

I think the knife is most powerful .. about the Handcannon LOL if Leon doesn't move his head he will kill the zombies all right... Kill 'em from laughter

I would say that the magnum would come close to being one of the most powerful weapons in the series. Pretty much a 1 shot kill weapon although ammo is always a problem with it.

The most powerful weapon is the Plagas Removal Laser

That tkes aaaaages to load, but I guess it does stop pretty much everythng in its tracks - if we're talking power..... hmm.... I'd have to go with the rocket launcher, I don't think i've ever come across anything it coldn't kill.
Did i mention I just came in pretty pssed from a reasonable night out and answered this post?
Something is very wrong with me.

How you kill Alexia?!?!?!......that's the MOST powerful weapon in the Entire series

Weskers sunglasses

everything that can own chris is powerfull

In RE4, agreed.

HUNK's arms