Rebecca became the newest member to the S.T.A.R.S. unit at only 18 years old. A brilliant field medicine specialist, she was eager to please her superiors and did almost anything they asked of her. Rebecca's first mission turned out to be the most incredible adventure of her life.

Rebecca was assigned to the S.T.A.R.S. Bravo Team, which was sent to investigate the murders in the Arclay Mountains. After their helicopter crashed, Bravo Team discovered an overturned federal vehicle that had housed convicted murderer Billy Coen. Figuring he must be responsible for the murders, they started a search for him. While searching, Rebecca found a train stopped in the middle of the forest, which began to move while she was inside, trapping her. Inside, she found zombies and other undead creatures, as well as Billy Coen.

At first she tried to arrest him, but soon realized she would need help getting off the train alive. The train eventually stopped near an old Umbrella training facility that used to be run by James Marcus. Rebecca and Billy fought through many creatures and began to uncover the true source of the murders- Umbrella was doing research on biological weapons. They also discovered that James Marcus was alive and was the cause of the viral outbreak. Eventually Rebecca and Billy triumphed over Marcus, destroying the T-virus infected leeches that took over his dead body. With the training facility destroyed and the Queen Leech defeated, Rebecca and Billy were finally free. After learning the truth about Billy's murder conviction, Rebecca decided it was best to let him go free, and chose to tell her superiors he died during the ordeal.

But Rebecca’s troubles had only just begun. After separating from Billy, Rebecca saw a large mansion she thought she could seek shelter in. Unfortunately, she discovered it was also crawling with T-virus monstrosities. Rebecca took refuge in a medicine room hoping that one of her S.T.A.R.S. teammates would find her, and eventually Chris Redfield did just that. The two of them fought through the mansion, eventually learning the truth behind Wesker’s treachery. They confronted him in the underground lab, and during their heated argument Wesker shot the sometimes-loud mouthed Rebecca in the chest. Fortunately she was wearing a bulletproof vest, which saved her life, allowing Rebecca to escape from the mansion with Chris, Jill and Barry.

Since the Mansion Incident Rebecca’s whereabouts are unknown.