Ashley Graham is the 20-year-old daughter of the President of the United States. She was kidnapped in 2004 (six years after the Raccoon City incident) by a religious cult in Europe. The President sent one of his best agents, Leon Kennedy, to rescue his daughter.

Leon found Ashley held captive in the cult’s church, which they escaped from after an encounter with the cult's leader, Osmund Saddler. Their escape from the church, however, was just the beginning of their adventures. Ashley, though scared, did her best to remain calm and help Leon in difficult situations. The two often worked in tandem to overcome various obstacles, and made quite a good team.

Unfortunately, Ashley had been infected with Las Plagas before Leon found her. Her condition slowly got worst over time, but with the help of Ada Wong and Luis Sera, they eventually found a cure. Ashley and Leon escaped the cult’s island with on a jet ski, after which the brave young woman was safely returned to her father.